Gastric cancer is malignancy of the stomach. The most common
variety is adenocarcinoma, usually found in the body of the stomach and in the
area between the esophagus (food pipe) and the stomach.
How prevalent is stomach cancer?
This varies among countries and by sex. Per 100,000 Japanese
population, for example, it is about 80 men and 30 women, white American men,
11, white American women, 7, British men, 18 and British women, 10. There has
been a impressive decline in incidence in North America, New Zealand and
Australia since 1930 but the reduction has been slower in Europe. The incidence
also seems higher among those with Type A blood. In the USA, cancer of the
stomach is relatively more common among Japanese American and Hispanic groups.
The death rate in the USA for gastric cancer is between 14,000 to 15,000 a year.
Sixty to 70 cases of these are men.
Is this cancer related to stomach ulcers?
Lifelong stomach ulcer caused by infection with Helicobacter
pylori appears to be strongly associated with cancer of the stomach, and so with
poor intake of antioxidant vitamins A, C and E, (and folic acid and calcium
also), and vegetables and fruits. The chronic inflammation in H. pylori
infection may also be a contributing factor in the formation of gastric cancer
among these patients.
What are the other etiologic factors?
Smoking is strongly related to cancer of the proximal portion
of the stomach. This is one unhealthy habit people should stay away from because
cigarettes kill hundreds of thousands slowly and "softly". This type of gastric
malignancy is also associated with obesity, gastro-esophageal reflux, high fat
intake, and is seen more among the more affluent people. Those in the lower
socio-economic bracket have been seen to be more prone to distal stomach cancer.
Does eating spicy food cause stomach cancer?
There is no scientific evidence to prove that ingesting spicy
food causes stomach cancer. There were some speculations that perhaps eating
very hot food and drinking hot beverages (as most Chinese do) day in and day out
may increase the risk for the development of cancer of the stomach. The jury is
still out there on this issue. But it is prudent to allow hot food or drink to
simmer down a bit before ingesting them. The caveat in almost everything is
"moderation."
How about eating smoked or salted fish?
Eating dried salted fish and smoked foods (or the nitrates in
them) have been suspected to increase the risk of stomach cancer. There seems to
be a higher incidence in Asia, particularly in Japan. Currently, however, we
find no absolute proof in the medical literature that confirms this, but I would
still advise caution here. As far as a good daily dietary regimen is concerned,
there is nothing better and safer than fresh fish, vegetables, fruits, high
fiber foods, and abstaining from red meat and eggs, which are high in
cholesterol and fats and low in fiber. Red meat has been implicated as a
causative factor in colon cancer and other cancers.
What are the symptoms to watch for?
They vary from person to person. Most do not even have
obvious symptoms before they are discovered. The symptoms could be a sense of
indigestion, upper stomach discomfort, gassy bloating feeling, loss of appetite
or pain on eating, loss of weight, tarry (blood in) stools, anemia, weakness and
fatigue, depending on the stage of the cancer. But any of these symptoms may
also be caused by other illnesses, which may not be as serious and are curable.
This is the reason why a regular medical check-up and seeing the doctor early
are important practices to prevent serious illnesses. If in doubt, consult your
physician.
What is the survival rate?
In the United States, the 5-year survival rate (the number of
patients alive after 5 years) is 90 percent (nine out of ten) among those where
the tumor is confined to the mucosa (stomach lining only) and 20 percent (one in
five) among those with large tumor and lymph node spread.
What is upper GI endoscopy?
This is an examination of the food pipe and stomach, using a
flexible fiberoptic lighted and magnified scope (about the caliber of the little
finger), that is passed through the mouth, down the throat, the esophagus and to
the stomach, to view any pathology, and do a biopsy, if needed. Endoscopic
Ultrasound is another recent diagnostic tool and is very helpful in assessing
the condition of the esophagus and stomach, and also for any lymph node or
regional spread of the cancer.
What is the treatment?
When stomach cancer is diagnosed, complete surgical excision
is the best option, if maximal survival rate is to be achieved. But this is not
always feasible, depending on the stage and anatomy of the disease. Subtotal
gastrectomy (removing part of the stomach involved in the cancer) has been found
to have the same survival rate benefit compared to removing the entire stomach.
No difference in the 5-year survival rate or postoperative mortality.
How about chemotherapy?
Current clinical evidence has shown that adjuvant chemotherapy (surgery plus
chemotherapy) versus surgery alone significantly increase survival rate. In
other words, it is not any better than surgery alone. It also found that those
who had adjuvant chemotherapy had much more postoperative complications. There
are various current chemotherapeutic agents that have not been fully evaluated
thus far. But ongoing researches continue. Hopefully, some day soon, the
"perfect" regimen will come along. Better yet, a vaccine to prevent gastric
cancer. In the meantime, let us stay away from unhealthy habits and prevent
diseases from coming our way, especially deadly cancers.