ood news for those
with reflux esophagitis. A recent open, parallel-group, multicenter randomized
controlled study in Sweden (LOTUS - Long-Term Usage of Acid Suppression Versus
Anti-reflux Surgery) showed that drug (Esomeprazole) is equally effective, if
not more, than surgery for reflux, according to the September 2008 issue of GUT.
What is Reflux Heartburn?
Reflux Heartburn is a milder stage of Reflux Esophagitis,
which is an inflammatory condition where Hydrocholoric Acid, normally produced
by the stomach to aid in the digestion of food, regurgitates (goes back up) to
the lower end of the esophagus (food pipe) which is connected to the stomach. In
most cases, the lower esophageal sphincter ("valve") is incompetent (loose) and
allows stomach acid and food to back up to the esophagus, a disease medically
known as Gastroesophageal Reflux Disease (GERD).
Why is acid reflux bad?
The stomach mucosa (lining) normally produces the digestive
acid and tolerates it much better than the esophagus does, which has a different
cell lining that is less resistant to the acid. Reflux of stomach acid into the
lower end of the esophagus, therefore, causes esophagitis (irritation,
inflammation, swelling, ulceration), which, if allowed to continue untreated,
could cause esophageal stricture (scarring) and narrowing, making the channel
connecting the food pipe to the stomach too small for food to pass through.
Is this condition common?
Yes, very common. Most patients complain of burning
discomfort in the pit of the stomach after meals or at night, while lying down,
allowing stomach acid to flow back to the esophagus. Many times the burning
disappears when the person gets up. The symptom could also be that of
indigestion or "sour stomach." People who take antacids, like Alka Seltzer,
Maalox, Tums, etc. could have GERD.
What are the possible complications of GERD?
Uncomplicated gastro-esophageal reflux responds well to
medical therapy, and may be tolerated for many years. However, some people on
treatment may still develop complications, like esophagitis, esophageal ulcer,
hemorrhage, esophageal stricture, and Barrett’s metaplasia (cell changes in the
esophagus that could transform to cancer).
What is the first-step treatment of GERD?
The initial management of patients with persisting symptoms
of GERD consists of (1) Changing diet (avoiding spices, caffeine, chocolate,
alcohol, cola drinks), (2) quitting cigarette smoking, (3) avoiding tight,
binding clothing, especially after a meal (4) refraining from lying down
immediately after a meal, and elevating the head of the bed when lying down to
keep gastric acid and contents in the stomach by gravity, and (5) taking
medication like esomeprazole under the close supervision of your physician.
Is surgery for GERD passé?
While these promising findings from the clinical research at
the Karolinska University Hospital in Huddinge, Sweden, and its partners in the
other dedicated centers in 11 European countries, show that GERD responds very
well to medical treatment, with even lesser post-op residual symptoms than those
treated with surgery (Laparoscopic Anti-Reflux Surgery, LARS, fundoplication),
surgery still has a role in managing resistant cases, and those with
complications of chronic GERD.
So, what is the final verdict?
In consonance with a caveat in medicine, positive findings
like this one will have to be confirmed and reconfirmed by other clinical
studies, before it becomes accepted as a standard convention in medical
practice. This wise principle in medicine is the reason advertised anecdotal
testimonials about untested herbals and "food supplements" in the market today
(claimed to have medicinal values) are considered scientifically baseless and
deemed downright dangerous for the consumers.
In the current poisoning catastrophe in China among more than
54,000 infants and children, who developed kidney stones, some dying of renal
failure, from consuming milk tainted with the toxic Melamine additive, where the
milk and milk products were advertised as excellent source of protein, is a case
in point, where extreme greed among unconscionable entrepreneurs and lack of
government oversight have brought great harm to the health and life of these
innocent victims.
As for this wonderful news about the preference today for
pills, instead of surgery, for GERD, these cohort studies are significant enough
to warrant further clinical application by the physicians, since H2 blocker
(acid pump inhibitor) drugs are presently an integral part of the management for
GERD anyway. Any new treatment where drugs are found to be equal to, or better
than surgery is a boon to medical therapeutics, a preferred regimen, and,
obviously, better for all of us.
Gastric ulcer used to be a surgical disease, where an
operation (to cut a part of the stomach out) was necessary to manage the
condition. Today, thanks to the progress in science, it is a medical disease,
where effective modern drugs are the accepted mainstay of therapy. Tuberculosis
used to kill millions by spreading like wild cancer, destroying most organs in
the body, the lungs, bones, brain, liver, kidneys, spleen, etc. Literally acting
like cancer. Today, majority of TB is cured by medications alone.
As an eternal optimist and a physician who has great faith in
medical science, I look forward to the day when cancers could be cured by
medications, or better yet, prevented by a healthy lifestyle, or by vaccine,
like the Gardasil vaccine today, recommended for young girls and boys (pre-teens
and older), which is highly (more than 99%) effective in blocking (pre-empting)
the development of cervical cancer.
That day will surely come. I don’t know when, but hopefully, for the sake of
mankind, it would be soon.